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Stroke due to atherosclerosis. Illustration of an arterial blockage (expanded view at upper right) causing a stroke (cerebrovascular accident, CVA). This stroke is due to a build-up of the plaque that forms in atherosclerosis. This blockage causes an interruption (occlusion) of the oxygenated blood supply. This will cause a stroke, where the brain is damaged due to hypoxia (lack of oxygen). The grey area at upper right shows the area of the brain affected by lack of oxygen. This type of stroke is known as an atherosclerotic stroke. Common causes are high blood pressure and arterial disease.